Highly parallel single-molecule identification of proteins in zeptomole-scale mixtures

The identification and quantification of proteins lags behind DNA sequencing methods in scale, sensitivity and dynamic range. Here we show that sparse amino acid sequence information can be obtained for individual protein molecules for thousands to millions of molecules in parallel. We demonstrate s...

Descripción completa

Detalles Bibliográficos
Autores principales: Swaminathan, Jagannath, Boulgakov, Alexander A., Hernandez, Erik T., Bardo, Angela M., Bachman, James L., Marotta, Joseph, Johnson, Amber M., Anslyn, Eric V., Marcotte, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482110/
https://www.ncbi.nlm.nih.gov/pubmed/30346938
http://dx.doi.org/10.1038/nbt.4278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482110/
https://www.ncbi.nlm.nih.gov/pubmed/30346938
http://dx.doi.org/10.1038/nbt.4278

Ejemplares similares