Neprilysin Inhibitor–Angiotensin II Receptor Blocker Combination Therapy (Sacubitril/valsartan) Suppresses Atherosclerotic Plaque Formation and Inhibits Inflammation in Apolipoprotein E- Deficient Mice

We assessed the effects of the sacubitril/valsartan combination drug (LCZ696), in comparison to valsartan alone, on the progression of atherosclerotic plaque formation and inflammatory gene expression in apolipoprotein E- deficient mice (apoE(−/−) mice). Seventy-two apoE(−/−) mice were fed a western...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Liu, Gangqiong, Zhou, Wenping, Zhang, Wenjing, Wang, Kai, Zhang, Jinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482143/
https://www.ncbi.nlm.nih.gov/pubmed/31019233
http://dx.doi.org/10.1038/s41598-019-42994-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482143/
https://www.ncbi.nlm.nih.gov/pubmed/31019233
http://dx.doi.org/10.1038/s41598-019-42994-1

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