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Modeling Exposure‐Driven Adverse Event Time Courses in Oncology Exemplified by Afatinib
Models were developed to characterize the relationship between afatinib exposure and diarrhea and rash/acne adverse event (AE) trajectories, and their predictive ability was assessed. Based on pooled data from seven phase II/III clinical studies including 998 patients, mixed‐effects models for order...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482278/ https://www.ncbi.nlm.nih.gov/pubmed/30681293 http://dx.doi.org/10.1002/psp4.12384 |