Azabicyclic vinyl sulfones for residue-specific dual protein labelling

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for cysteine relative to other amino acids that have nucleophilic side-chains,...

Descripción completa

Detalles Bibliográficos
Autores principales: Gil de Montes, Enrique, Jiménez-Moreno, Ester, Oliveira, Bruno L., Navo, Claudio D., Cal, Pedro M. S. D., Jiménez-Osés, Gonzalo, Robina, Inmaculada, Moreno-Vargas, Antonio J., Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482879/
https://www.ncbi.nlm.nih.gov/pubmed/31057781
http://dx.doi.org/10.1039/c9sc00125e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482879/
https://www.ncbi.nlm.nih.gov/pubmed/31057781
http://dx.doi.org/10.1039/c9sc00125e

Ejemplares similares