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Azabicyclic vinyl sulfones for residue-specific dual protein labelling

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for cysteine relative to other amino acids that have nucleophilic side-chains,...

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Detalles Bibliográficos
Autores principales:	Gil de Montes, Enrique, Jiménez-Moreno, Ester, Oliveira, Bruno L., Navo, Claudio D., Cal, Pedro M. S. D., Jiménez-Osés, Gonzalo, Robina, Inmaculada, Moreno-Vargas, Antonio J., Bernardes, Gonçalo J. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482879/ https://www.ncbi.nlm.nih.gov/pubmed/31057781 http://dx.doi.org/10.1039/c9sc00125e

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