Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N–P-bond-forming kinase

Phosphoramidon is a potent metalloprotease inhibitor and a widespread tool in cell biology research. It contains a dipeptide backbone that is uniquely linked to a 6-deoxysugar via a phosphoramidate bridge. Herein, we report the identification of a gene cluster for the formation of phosphoramidon and...

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Detalles Bibliográficos
Autores principales: Baulig, Alexandra, Helmle, Irina, Bader, Marius, Wolf, Felix, Kulik, Andreas, Al-Dilaimi, Arwa, Wibberg, Daniel, Kalinowski, Jörn, Gross, Harald, Kaysser, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482885/
https://www.ncbi.nlm.nih.gov/pubmed/31057776
http://dx.doi.org/10.1039/c9sc00641a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482885/
https://www.ncbi.nlm.nih.gov/pubmed/31057776
http://dx.doi.org/10.1039/c9sc00641a

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