Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design

The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the first clinical agent has now been approved, but PPIs remain difficult targets for the development of small molecule ligands. This article describes a highly efficient approach to...

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Detalles Bibliográficos
Autores principales: Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo, Jesus, Searcey, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482886/
https://www.ncbi.nlm.nih.gov/pubmed/31057779
http://dx.doi.org/10.1039/c9sc00059c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482886/
https://www.ncbi.nlm.nih.gov/pubmed/31057779
http://dx.doi.org/10.1039/c9sc00059c

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