Cargando…
Identification of selective protein–protein interaction inhibitors using efficient in silico peptide-directed ligand design
The development of protein–protein interaction (PPI) inhibitors with therapeutic value is of increasing importance as the first clinical agent has now been approved, but PPIs remain difficult targets for the development of small molecule ligands. This article describes a highly efficient approach to...
Autores principales: | Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo, Jesus, Searcey, Mark |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482886/ https://www.ncbi.nlm.nih.gov/pubmed/31057779 http://dx.doi.org/10.1039/c9sc00059c |
Ejemplares similares
-
In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery
por: Howell, Lesley Ann, et al.
Publicado: (2020) -
Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
por: Goddard, Zoë Rachael, et al.
Publicado: (2020) -
Cytotoxicity of Pyrazine-Based Cyclometalated (C^N(pz)^C)Au(III) Carbene Complexes: Impact of the Nature of the
Ancillary Ligand on the Biological Properties
por: Bertrand, Benoît, et al.
Publicado: (2017) -
Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment
por: Nepravishta, Ridvan, et al.
Publicado: (2018) -
Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1
por: Beekman, Andrew Michael, et al.
Publicado: (2017)