Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency()

The mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1(m/m); Per2(m/m) double mutations display a decrease in female fertility starting approximately at 20 weeks old, with significantly less pups born from 32 weeks old onwards. Hi...

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Detalles Bibliográficos
Autores principales: Zheng, Yating, Liu, Chao, Li, Yan, Jiang, Haijuan, Yang, Peixin, Tang, Jing, Xu, Ying, Wang, Han, He, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483055/
https://www.ncbi.nlm.nih.gov/pubmed/30452546
http://dx.doi.org/10.1093/biolre/ioy245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483055/
https://www.ncbi.nlm.nih.gov/pubmed/30452546
http://dx.doi.org/10.1093/biolre/ioy245

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