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Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency()
The mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1(m/m); Per2(m/m) double mutations display a decrease in female fertility starting approximately at 20 weeks old, with significantly less pups born from 32 weeks old onwards. Hi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483055/ https://www.ncbi.nlm.nih.gov/pubmed/30452546 http://dx.doi.org/10.1093/biolre/ioy245 |