Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular inter...

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Detalles Bibliográficos
Autores principales: Zheng, Wang, Cai, Ruiqi, Hofmann, Laura, Nesin, Vasyl, Hu, Qiaolin, Long, Wentong, Fatehi, Mohammad, Liu, Xiong, Hussein, Shaimaa, Kong, Tim, Li, Jingru, Light, Peter E., Tang, Jingfeng, Flockerzi, Veit, Tsiokas, Leonidas, Chen, Xing-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483072/
https://www.ncbi.nlm.nih.gov/pubmed/29425510
http://dx.doi.org/10.1016/j.celrep.2018.01.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483072/
https://www.ncbi.nlm.nih.gov/pubmed/29425510
http://dx.doi.org/10.1016/j.celrep.2018.01.042

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