Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease

Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice w...

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Detalles Bibliográficos
Autores principales: Washburn, Michael L, Crosby, Renae, Remlinger, Katja, Wang, Feng, Creech, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483135/
https://www.ncbi.nlm.nih.gov/pubmed/31041337
http://dx.doi.org/10.1093/ofid/ofz106
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author Washburn, Michael L
Crosby, Renae
Remlinger, Katja
Wang, Feng
Creech, Donald
author_facet Washburn, Michael L
Crosby, Renae
Remlinger, Katja
Wang, Feng
Creech, Donald
author_sort Washburn, Michael L
collection PubMed
description Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.
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spelling pubmed-64831352019-04-30 Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease Washburn, Michael L Crosby, Renae Remlinger, Katja Wang, Feng Creech, Donald Open Forum Infect Dis Brief Reports Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome. Oxford University Press 2019-03-07 /pmc/articles/PMC6483135/ /pubmed/31041337 http://dx.doi.org/10.1093/ofid/ofz106 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Washburn, Michael L
Crosby, Renae
Remlinger, Katja
Wang, Feng
Creech, Donald
Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title_full Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title_fullStr Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title_full_unstemmed Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title_short Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease
title_sort therapeutically attenuating neutrophil recruitment with a cxcr2 antagonist in combination with oseltamivir ameliorates influenza-induced lung injury and disease
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483135/
https://www.ncbi.nlm.nih.gov/pubmed/31041337
http://dx.doi.org/10.1093/ofid/ofz106
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