Structural and functional characterization of an otopetrin family proton channel

The otopetrin (OTOP) proteins were recently characterized as proton channels. Here we present the cryo-EM structure of OTOP3 from Xenopus tropicalis (XtOTOP3) along with functional characterization of the channel. XtOTOP3 forms a homodimer with each subunit containing 12 transmembrane helices that c...

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Detalles Bibliográficos
Autores principales: Chen, Qingfeng, Zeng, Weizhong, She, Ji, Bai, Xiao-chen, Jiang, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483595/
https://www.ncbi.nlm.nih.gov/pubmed/30973323
http://dx.doi.org/10.7554/eLife.46710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483595/
https://www.ncbi.nlm.nih.gov/pubmed/30973323
http://dx.doi.org/10.7554/eLife.46710

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