NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

Hepatocellular carcinoma (HCC) is a deadly human cancer associated with chronic inflammation. The cytosolic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC is unknown. Here we investigated the role of NLRP12 in HCC using mouse models of HCC induced by...

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Detalles Bibliográficos
Autores principales: Udden, SM Nashir, Kwak, Youn-Tae, Godfrey, Victoria, Khan, Md Abdul Wadud, Khan, Shahanshah, Loof, Nicolas, Peng, Lan, Zhu, Hao, Zaki, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483596/
https://www.ncbi.nlm.nih.gov/pubmed/30990169
http://dx.doi.org/10.7554/eLife.40396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483596/
https://www.ncbi.nlm.nih.gov/pubmed/30990169
http://dx.doi.org/10.7554/eLife.40396

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