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NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
Hepatocellular carcinoma (HCC) is a deadly human cancer associated with chronic inflammation. The cytosolic pathogen sensor NLRP12 has emerged as a negative regulator of inflammation, but its role in HCC is unknown. Here we investigated the role of NLRP12 in HCC using mouse models of HCC induced by...
Autores principales: | Udden, SM Nashir, Kwak, Youn-Tae, Godfrey, Victoria, Khan, Md Abdul Wadud, Khan, Shahanshah, Loof, Nicolas, Peng, Lan, Zhu, Hao, Zaki, Hasan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483596/ https://www.ncbi.nlm.nih.gov/pubmed/30990169 http://dx.doi.org/10.7554/eLife.40396 |
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