Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique...

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Detalles Bibliográficos
Autores principales: Kim, Byungchul, Wang, Yen-Chih, Hespen, Charles W, Espinosa, Juliel, Salje, Jeanne, Rangan, Kavita J, Oren, Deena A, Kang, Jin Young, Pedicord, Virginia A, Hang, Howard C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483599/
https://www.ncbi.nlm.nih.gov/pubmed/30969170
http://dx.doi.org/10.7554/eLife.45343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483599/
https://www.ncbi.nlm.nih.gov/pubmed/30969170
http://dx.doi.org/10.7554/eLife.45343

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