Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

Iron deficiency is present in ~50% of heart failure (HF) patients. Large multicenter trials have shown that treatment of iron deficiency with i.v. iron benefits HF patients, but the underlying mechanisms are not known. To investigate the actions of iron deficiency on the heart, mice were fed an iron...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Yu Jin, Luo, Antao, Park, Kyung Chan, Loonat, Aminah A., Lakhal-Littleton, Samira, Robbins, Peter A., Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483648/
https://www.ncbi.nlm.nih.gov/pubmed/30779710
http://dx.doi.org/10.1172/jci.insight.125618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483648/
https://www.ncbi.nlm.nih.gov/pubmed/30779710
http://dx.doi.org/10.1172/jci.insight.125618

Ejemplares similares