Discovery of selective activators of PRC2 mutant EED-I363M

Many common disease-causing mutations result in loss-of-function (LOF) of the proteins in which they occur. LOF mutations have proven recalcitrant to pharmacologic intervention, presenting a challenge for the development of targeted therapeutics. Polycomb repressive complex 2 (PRC2), which contains...

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Detalles Bibliográficos
Autores principales: Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484020/
https://www.ncbi.nlm.nih.gov/pubmed/31024026
http://dx.doi.org/10.1038/s41598-019-43005-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484020/
https://www.ncbi.nlm.nih.gov/pubmed/31024026
http://dx.doi.org/10.1038/s41598-019-43005-z

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