AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8-oxoguanine in DNA followed by repair through the base excision repair (BER) pathway. We reported earlier that AP endonuclease 1 (Apex1) not only participates directly in BE...

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Detalles Bibliográficos
Autores principales: Pei, De-Sheng, Jia, Pan-Pan, Luo, Juan-Juan, Liu, Wei, Strauss, Phyllis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484078/
https://www.ncbi.nlm.nih.gov/pubmed/31024003
http://dx.doi.org/10.1038/s41419-019-1578-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484078/
https://www.ncbi.nlm.nih.gov/pubmed/31024003
http://dx.doi.org/10.1038/s41419-019-1578-1

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