Cargando…

AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8-oxoguanine in DNA followed by repair through the base excision repair (BER) pathway. We reported earlier that AP endonuclease 1 (Apex1) not only participates directly in BE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pei, De-Sheng, Jia, Pan-Pan, Luo, Juan-Juan, Liu, Wei, Strauss, Phyllis R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484078/ https://www.ncbi.nlm.nih.gov/pubmed/31024003 http://dx.doi.org/10.1038/s41419-019-1578-1

Ejemplares similares

A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β
por: Pei, De-Sheng, et al.
Publicado: (2011)

An AP Endonuclease 1–DNA Polymerase β Complex: Theoretical Prediction of Interacting Surfaces
por: Abyzov, Alexej, et al.
Publicado: (2008)

Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells
por: Lefevre, Sophie, et al.
Publicado: (2012)

Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases
por: Yudkina, Anna V, et al.
Publicado: (2023)

Thermodynamics of Damaged DNA Binding and Catalysis by Human AP Endonuclease 1
por: Miroshnikova, A. D., et al.
Publicado: (2016)

Characterizing inhibitors of human AP endonuclease 1
por: Pidugu, Lakshmi S., et al.
Publicado: (2023)

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
por: Chang, In-Youb, et al.
Publicado: (2005)

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
por: Chang, In-Youb, et al.
Publicado: (2005)

Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.
por: Herring, C. J., et al.
Publicado: (1998)

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe
por: Nilsen, Line, et al.
Publicado: (2012)

African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA
por: Redrejo-Rodríguez, Modesto, et al.
Publicado: (2009)

AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop
por: Hoitsma, Nicole M, et al.
Publicado: (2020)

Genetic and Biochemical Characterization of Human AP Endonuclease 1 Mutants Deficient in Nucleotide Incision Repair Activity
por: Gelin, Aurore, et al.
Publicado: (2010)

CiAPEX2 and CiP0, candidates of AP endonucleases in Ciona intestinalis, have 3′-5′ exonuclease activity and contribute to protection against oxidative stress
por: Funakoshi, Masafumi, et al.
Publicado: (2017)

Complementary Functions of Plant AP Endonucleases and AP Lyases during DNA Repair of Abasic Sites Arising from C:G Base Pairs
por: Jordano-Raya, Marina, et al.
Publicado: (2021)

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1
por: Malina, Jaroslav, et al.
Publicado: (2015)

Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. II. Kinetic properties of AP DNA endonucleases in rat liver chromatin.
por: Kim, Y. S., et al.
Publicado: (1990)

An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis
por: Li, Yan, et al.
Publicado: (2015)

Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin.
por: Kim, Y. S., et al.
Publicado: (1990)

Functional Role of N-Terminal Extension of Human AP Endonuclease 1 In Coordination of Base Excision DNA Repair via Protein–Protein Interactions
por: Moor, Nina, et al.
Publicado: (2020)

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
por: SenGupta, Tanima, et al.
Publicado: (2013)

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis
por: Yui, Naoko, et al.
Publicado: (2014)

Correction: An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis
Publicado: (2015)

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
por: Beaver, Jill M., et al.
Publicado: (2015)

Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma
por: Pascut, Devis, et al.
Publicado: (2019)

Base Excision Repair AP-Endonucleases-Like Genes Modulate DNA Damage Response and Virulence of the Human Pathogen Cryptococcus neoformans
por: Oliveira, Rayssa Karla de Medeiros, et al.
Publicado: (2021)

Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair
por: Thompson, Marlo K., et al.
Publicado: (2021)

Thermodynamics of the DNA Repair Process by Endonuclease VIII
por: Kladova, O. A., et al.
Publicado: (2019)

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
por: Zaky, Amira, et al.
Publicado: (2008)

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites
por: Collier, Christopher, et al.
Publicado: (2012)

A unique DNA-binding mode of African swine fever virus AP endonuclease
por: Chen, Yiqing, et al.
Publicado: (2020)

Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy
por: SenGupta, Tanima, et al.
Publicado: (2018)

Binding of AP Endonuclease-1 to G-Quadruplex DNA Depends on the N-Terminal Domain, Mg(2+), and Ionic Strength
por: Fleming, Aaron M., et al.
Publicado: (2021)

Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk
por: Park, Jae Sung, et al.
Publicado: (2014)

Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1
por: Kuznetsova, Alexandra A., et al.
Publicado: (2018)

Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5
por: Busso, Carlos S., et al.
Publicado: (2011)

AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis
por: Lee, Jiyoon, et al.
Publicado: (2014)

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation
por: Dornfeld, Ken, et al.
Publicado: (2005)

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells
por: Chattopadhyay, Ranajoy, et al.
Publicado: (2006)

Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line
por: Kim, Daria V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c8fq5khthr44i8o1edhiv17m2o