Synapse loss and progress of Alzheimer’s disease -A network model

We present observational evidence from studies on primary cortical cultures from AD transgenic mice, APPSwe/PS1ΔE9 (APP/PS1) mice, for significant decrease in total spine density at DIV-15 and onward. This indicates reduction in potential healthy synapses and strength of connections among neurons. B...

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Detalles Bibliográficos
Autores principales: Kashyap, G., Bapat, D., Das, D., Gowaikar, R., Amritkar, R. E., Rangarajan, G., Ravindranath, V., Ambika, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484103/
https://www.ncbi.nlm.nih.gov/pubmed/31024073
http://dx.doi.org/10.1038/s41598-019-43076-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484103/
https://www.ncbi.nlm.nih.gov/pubmed/31024073
http://dx.doi.org/10.1038/s41598-019-43076-y

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