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Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture

The inactive X chromosome (Xi) serves as a model for establishment and maintenance of repressed chromatin and the function of polycomb repressive complexes (PRC1/2). Here we show that Xi transiently relocates from the nuclear periphery towards the interior during its replication, in a process depend...

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Detalles Bibliográficos
Autores principales: Stewart, Emma R., Turner, Robert M. L., Newling, Katherine, Ridings-Figueroa, Rebeca, Scott, Victoria, Ashton, Peter D., Ainscough, Justin F. X., Coverley, Dawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484225/
https://www.ncbi.nlm.nih.gov/pubmed/30692537
http://dx.doi.org/10.1038/s41467-018-08072-2