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Positive Feedback Loops in Alzheimer’s Disease: The Alzheimer’s Feedback Hypothesis
The dominant model for Alzheimer’s disease (AD) is the amyloid cascade hypothesis, in which the accumulation of excess amyloid-β (Aβ) leads to inflammation, excess glutamate and intracellular calcium, oxidative stress, tau hyperphosphorylation and tangle formation, neuronal loss, and ultimately deme...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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IOS Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484277/ https://www.ncbi.nlm.nih.gov/pubmed/30282364 http://dx.doi.org/10.3233/JAD-180583 |