The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis

The main manifestation of systemic sclerosis (SSc) is the overproduction of extracellular matrix, predominantly type I collagen. This study was undertaken to evaluate the effects of noncytotoxic doses of the topoisomerase I inhibitor camptothecin (CPT) on collagen production in the activated dermal...

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Detalles Bibliográficos
Autores principales: Czuwara-Ladykowska, Joanna, Makiela, Barbara, Smith, Edwin A, Trojanowska, Maria, Rudnicka, Lidia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64844/
https://www.ncbi.nlm.nih.gov/pubmed/11549373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64844/
https://www.ncbi.nlm.nih.gov/pubmed/11549373

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