A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes

The rate of RNA polymerase II (RNAPII) elongation has an important role in the control of alternative splicing (AS); however, the in vivo consequences of an altered elongation rate are unknown. Here, we generated mouse embryonic stem cells (ESCs) knocked in for a slow elongating form of RNAPII. We s...

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Detalles Bibliográficos
Autores principales: Maslon, Magdalena M, Braunschweig, Ulrich, Aitken, Stuart, Mann, Abigail R, Kilanowski, Fiona, Hunter, Chris J, Blencowe, Benjamin J, Kornblihtt, Alberto R, Adams, Ian R, Cáceres, Javier F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484407/
https://www.ncbi.nlm.nih.gov/pubmed/30988016
http://dx.doi.org/10.15252/embj.2018101244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484407/
https://www.ncbi.nlm.nih.gov/pubmed/30988016
http://dx.doi.org/10.15252/embj.2018101244

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