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Notch1 activates angiogenic regulator Netrin4 in endothelial cells

Netrin4 (NTN4) is a chemotropic factor that regulates angiogenesis. We found that endothelial expression of the activated, intracellular domain of Notch1 (NICD1), significantly up‐regulated NTN4 mRNA as well as intracellular NTN4 protein in both transgenic mice and cultured human umbilical vein endo...

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Detalles Bibliográficos
Autores principales: Liu, Qiang, Allen, Thaddeus D., Song, Wei, Wada, Youichiro, Lobe, Corrinne G., Liu, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484422/
https://www.ncbi.nlm.nih.gov/pubmed/30784178
http://dx.doi.org/10.1111/jcmm.14240