Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Methods to measure cellular target engagement are increasingly being used in early drug discovery. The Cellular Thermal Shift Assay (CETSA) is one such method. CETSA can investigate target engagement by measuring changes in protein thermal stability upon compound binding within the intracellular env...

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Detalles Bibliográficos
Autores principales: Shaw, Joseph, Dale, Ian, Hemsley, Paul, Leach, Lindsey, Dekki, Nancy, Orme, Jonathan P., Talbot, Verity, Narvaez, Ana J., Bista, Michal, Martinez Molina, Daniel, Dabrowski, Michael, Main, Martin J., Gianni, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484527/
https://www.ncbi.nlm.nih.gov/pubmed/30543471
http://dx.doi.org/10.1177/2472555218813332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484527/
https://www.ncbi.nlm.nih.gov/pubmed/30543471
http://dx.doi.org/10.1177/2472555218813332

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