Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma

Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated RAS/RAF/MEK/ERK signaling. In this study, we report the identification of a novel recurrent BRAF insertion (p.V504_R506dup) in five PA cases harboring exclusively this somatic tandem duplication. This recurrent alteration lea...

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Detalles Bibliográficos
Autores principales: Khater, Fida, Langlois, Sylvie, Cassart, Pauline, Roy, Anne-Marie, Lajoie, Mathieu, Healy, Jasmine, Richer, Chantal, St-Onge, Pascal, Piché, Nelson, Perreault, Sebastien, Cellot, Sonia, Marzouki, Monia, Jabado, Nada, Sinnett, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484687/
https://www.ncbi.nlm.nih.gov/pubmed/30575814
http://dx.doi.org/10.1038/s41388-018-0623-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484687/
https://www.ncbi.nlm.nih.gov/pubmed/30575814
http://dx.doi.org/10.1038/s41388-018-0623-3

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