Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange

Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans. By specifying that APAP metabolism, reactive metabolite formation, glutathione depletion, and mitigation of mitochondrial damage within indi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kennedy, Ryan C, Smith, Andrew K, Ropella, Glen E P, McGill, Mitchell R, Jaeschke, Hartmut, Hunt, C Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Intercellular Communication in Acetaminophen-Induced Pericentral Necrosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484890/
https://www.ncbi.nlm.nih.gov/pubmed/30698817
http://dx.doi.org/10.1093/toxsci/kfz029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484890/
https://www.ncbi.nlm.nih.gov/pubmed/30698817
http://dx.doi.org/10.1093/toxsci/kfz029

Ejemplares similares