Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6)

BACKGROUND: Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of perioperative systemic therapy to CRS-HIPEC improves oncological outcomes. METHODS:...

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Detalles Bibliográficos
Autores principales: Rovers, Koen P., Bakkers, Checca, Simkens, Geert A. A. M., Burger, Jacobus W. A., Nienhuijs, Simon W., Creemers, Geert-Jan M., Thijs, Anna M. J., Brandt-Kerkhof, Alexandra R. M., Madsen, Eva V. E., Ayez, Ninos, de Boer, Nadine L., van Meerten, Esther, Tuynman, Jurriaan B., Kusters, Miranda, Sluiter, Nina R., Verheul, Henk M. W., van der Vliet, Hans J., Wiezer, Marinus J., Boerma, Djamila, Wassenaar, Emma C. E., Los, Maartje, Hunting, Cornelis B., Aalbers, Arend G. J., Kok, Niels F. M., Kuhlmann, Koert F. D., Boot, Henk, Chalabi, Myriam, Kruijff, Schelto, Been, Lukas B., van Ginkel, Robert J., de Groot, Derk Jan A., Fehrmann, Rudolf S. N., de Wilt, Johannes H. W., Bremers, Andreas J. A., de Reuver, Philip R., Radema, Sandra A., Herbschleb, Karin H., van Grevenstein, Wilhelmina M. U., Witkamp, Arjen J., Koopman, Miriam, Haj Mohammad, Nadia, van Duyn, Eino B., Mastboom, Walter J. B., Mekenkamp, Leonie J. M., Nederend, Joost, Lahaye, Max J., Snaebjornsson, Petur, Verhoef, Cornelis, van Laarhoven, Hanneke W. M., Zwinderman, Aeilko H., Bouma, Jeanette M., Kranenburg, Onno, van ‘t Erve, Iris, Fijneman, Remond J. A., Dijkgraaf, Marcel G. W., Hemmer, Patrick H. J., Punt, Cornelis J. A., Tanis, Pieter J., de Hingh, Ignace H. J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485075/
https://www.ncbi.nlm.nih.gov/pubmed/31023318
http://dx.doi.org/10.1186/s12885-019-5545-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485075/
https://www.ncbi.nlm.nih.gov/pubmed/31023318
http://dx.doi.org/10.1186/s12885-019-5545-0

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