Age-related dysfunction of the DNA damage response in intestinal stem cells

BACKGROUND: Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, the influence of aging on the functions of ISCs is largely unknown. The mutatio...

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Detalles Bibliográficos
Autores principales: Watanabe, Koichiro, Ikuno, Yasuaki, Kakeya, Yumi, Ikeno, Shinsuke, Taniura, Hitomi, Kurono, Masayoshi, Minemori, Keito, Katsuyama, Yu, Naka-Kaneda, Hayato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485179/
https://www.ncbi.nlm.nih.gov/pubmed/31057688
http://dx.doi.org/10.1186/s41232-019-0096-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485179/
https://www.ncbi.nlm.nih.gov/pubmed/31057688
http://dx.doi.org/10.1186/s41232-019-0096-y

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