Cargando…

Age-related dysfunction of the DNA damage response in intestinal stem cells

BACKGROUND: Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, the influence of aging on the functions of ISCs is largely unknown. The mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Koichiro, Ikuno, Yasuaki, Kakeya, Yumi, Ikeno, Shinsuke, Taniura, Hitomi, Kurono, Masayoshi, Minemori, Keito, Katsuyama, Yu, Naka-Kaneda, Hayato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485179/ https://www.ncbi.nlm.nih.gov/pubmed/31057688 http://dx.doi.org/10.1186/s41232-019-0096-y

Ejemplares similares

Functional similarities of microRNAs across different types of tissue stem cells in aging
por: Watanabe, Koichiro, et al.
Publicado: (2018)

Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells
por: Hisamatsu, Daisuke, et al.
Publicado: (2016)

New Routes for Refinery of Biogenic Platform Chemicals Catalyzed by Cerium Oxide-supported Ruthenium Nanoparticles in Water
por: Mizugaki, Tomoo, et al.
Publicado: (2017)

Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues
por: Hisamatsu, Daisuke, et al.
Publicado: (2016)

Successful Treatment of Intestinal Mycosis Caused by a Simultaneous Infection with Lichtheimia ramosa and Aspergillus calidoustus
por: Kaneko, Yukihiro, et al.
Publicado: (2018)

Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota
por: Tanigawa, Tetsuya, et al.
Publicado: (2021)

Intestinal damage precedes mucosal immune dysfunction in SIV infection
por: Hensley-McBain, Tiffany, et al.
Publicado: (2018)

Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage
por: Shimada, Sunao, et al.
Publicado: (2019)

Bevacizumab-induced intestinal perforation in a patient with inoperable breast cancer: a case report and review of the literature
por: Fujii, Yusuke, et al.
Publicado: (2018)

Spinal Metastasis from Struma Ovarii: Case Report and Review of the Literature
por: Kobayashi, Kazuyoshi, et al.
Publicado: (2015)

Parathyroid carcinoma detected within the thyroid
por: Otake, Koki, et al.
Publicado: (2021)

High wettability of liquid caesium iodine with solid uranium dioxide
por: Kurosaki, Ken, et al.
Publicado: (2017)

Intestinal Stem Cells Damaged by Deoxycholic Acid via AHR Pathway Contributes to Mucosal Barrier Dysfunction in High-Fat Feeding Mice
por: Liu, Leheng, et al.
Publicado: (2022)

High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A
por: Sugimura, Naoki, et al.
Publicado: (2019)

A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35
por: Hirayama, Tasuku, et al.
Publicado: (2018)

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells
por: Moorefield, Emily C., et al.
Publicado: (2017)

Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
por: Kuzumoto, Takuya, et al.
Publicado: (2021)

High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
por: Sumi-Akamaru, Hisae, et al.
Publicado: (2016)

Muscle and intestinal damage in triathletes
por: Tota, Łukasz, et al.
Publicado: (2019)

Optimal implantation site of transponders for identification of experimental swine
por: Nakamura, Shintaro, et al.
Publicado: (2018)

Differences in nutritional status and activities of daily living and mobility in elderly hospitalized patients with heart failure
por: Kitamura, Masahiro, et al.
Publicado: (2019)

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
por: Sato, Taku, et al.
Publicado: (2020)

Evaluation of sperm DNA damage in bulls by TUNEL assay as a parameter of semen quality
por: TAKEDA, Kumiko, et al.
Publicado: (2015)

Fibroblasts in intestinal homeostasis, damage, and repair
por: Chalkidi, Niki, et al.
Publicado: (2022)

Semi-3D cultures using Laminin 221 as a coating material for human induced pluripotent stem cells
por: Nakashima, Yoshiki, et al.
Publicado: (2022)

A novel form of transcutaneous electrical nerve stimulation for the reduction of dysesthesias caused by spinal nerve dysfunction: A case series
por: Nishi, Yuki, et al.
Publicado: (2022)

TLR9 is important for protection against intestinal damage and for intestinal repair
por: II, William Alfred Rose, et al.
Publicado: (2012)

Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports
por: Tomioka, Hiromi, et al.
Publicado: (2016)

Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period
por: Watanabe, Yusuke, et al.
Publicado: (2019)

Curcumin β‐D‐glucuronide exhibits anti–tumor effects on oxaliplatin‐resistant colon cancer with less toxicity in vivo
por: Ozawa‐Umeta, Hitomi, et al.
Publicado: (2020)

Small intestine dysfunction in Parkinson’s disease
por: Dutkiewicz, Justyna, et al.
Publicado: (2015)

Function and dysfunction of plasma cells in intestine
por: Wang, Xue, et al.
Publicado: (2019)

Sepsis and Intestinal Microvascular Endothelial Dysfunction
por: Chen, De-Chang
Publicado: (2017)

Intestinal Lymphatic Dysfunction in Kidney Disease
por: Zhong, Jianyong, et al.
Publicado: (2023)

Delayed sleep-wake rhythm is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with major depressive disorder
por: Takaesu, Yoshikazu, et al.
Publicado: (2022)

Middle Ear and Eustachian Tube
por: Kurono, Yuichi, et al.
Publicado: (2005)

Severe pulmonary tuberculosis complicating Ileocecal intussusception due to intestinal tuberculosis: a case report
por: Nakamura, Shigeki, et al.
Publicado: (2008)

Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments
por: Yanai, Hidekatsu, et al.
Publicado: (2023)

Protective Effect of Brazilian Propolis against Liver Damage with Cholestasis in Rats Treated with α-Naphthylisothiocyanate
por: Nakamura, Tadashi, et al.
Publicado: (2013)

Prevention of downhill walking-induced muscle damage by non-damaging downhill walking
por: Maeo, Sumiaki, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_00sl7keu402g61pdmsvubl3df6