Application of Threonine Aldolases for the Asymmetric Synthesis of α‐Quaternary α‐Amino Acids

We report the synthesis of diverse β‐hydroxy‐α,α‐dialkyl‐α‐amino acids with perfect stereoselectivity for the α‐quaternary center through the action of l‐ and d‐specific threonine aldolases. A wide variety of aliphatic and aromatic aldehydes were accepted by the enzymes and conversions up to >80 ...

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Detalles Bibliográficos
Autores principales: Blesl, Julia, Trobe, Melanie, Anderl, Felix, Breinbauer, Rolf, Strohmeier, Gernot A., Fesko, Kateryna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485451/
https://www.ncbi.nlm.nih.gov/pubmed/31057675
http://dx.doi.org/10.1002/cctc.201800611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485451/
https://www.ncbi.nlm.nih.gov/pubmed/31057675
http://dx.doi.org/10.1002/cctc.201800611

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