Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

PTEN is a well-characterized tumour-suppressor gene that is lost or mutated in about half of metastatic castration-resistant prostate cancers and in many other human cancers. The restoration of functional PTEN as a treatment for prostate cancer has however proven difficult. Here, we show that PTEN m...

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Detalles Bibliográficos
Autores principales: Islam, Mohammad Ariful, Xu, Yingjie, Tao, Wei, Ubellacker, Jessalyn M., Lim, Michael, Aum, Daniel, Lee, Gha Young, Zhou, Kun, Zope, Harshal, Yu, Mikyung, Cao, Wuji, Oswald, James Trevor, Dinarvand, Meshkat, Mahmoudi, Morteza, Langer, Robert, Kantoff, Philip W., Farokhzad, Omid C., Zetter, Bruce R., Shi, Jinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486184/
https://www.ncbi.nlm.nih.gov/pubmed/31015614
http://dx.doi.org/10.1038/s41551-018-0284-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486184/
https://www.ncbi.nlm.nih.gov/pubmed/31015614
http://dx.doi.org/10.1038/s41551-018-0284-0

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