Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A(2)

Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the ir...

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Detalles Bibliográficos
Autores principales: Lucotti, Serena, Cerutti, Camilla, Soyer, Magali, Gil-Bernabé, Ana M., Gomes, Ana L., Allen, Philip D., Smart, Sean, Markelc, Bostjan, Watson, Karla, Armstrong, Paul C., Mitchell, Jane A., Warner, Timothy D., Ridley, Anne J., Muschel, Ruth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486338/
https://www.ncbi.nlm.nih.gov/pubmed/30907747
http://dx.doi.org/10.1172/JCI121985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486338/
https://www.ncbi.nlm.nih.gov/pubmed/30907747
http://dx.doi.org/10.1172/JCI121985

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