The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5′ and 3′ ends of genes

The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8;21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We used precision nuclear run-on transcription sequencing (PROseq) to define the glob...

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Detalles Bibliográficos
Autores principales: Sampathi, Shilpa, Acharya, Pankaj, Zhao, Yue, Wang, Jing, Stengel, Kristy R, Liu, Qi, Savona, Michael R, Hiebert, Scott W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486546/
https://www.ncbi.nlm.nih.gov/pubmed/30805632
http://dx.doi.org/10.1093/nar/gkz127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486546/
https://www.ncbi.nlm.nih.gov/pubmed/30805632
http://dx.doi.org/10.1093/nar/gkz127

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