Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks

Multiple pathways counteract DNA replication stress to prevent genomic instability and tumorigenesis. The recently identified human SDE2 is a genome surveillance protein regulated by PCNA, a DNA clamp and processivity factor at replication forks. Here, we show that SDE2 cleavage after its ubiquitin-...

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Detalles Bibliográficos
Autores principales: Rageul, Julie, Park, Jennifer J, Jo, Ukhyun, Weinheimer, Alexandra S, Vu, Tri T M, Kim, Hyungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486553/
https://www.ncbi.nlm.nih.gov/pubmed/30698750
http://dx.doi.org/10.1093/nar/gkz054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486553/
https://www.ncbi.nlm.nih.gov/pubmed/30698750
http://dx.doi.org/10.1093/nar/gkz054

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