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Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system discovered using bacteria has been repurposed for genome editing in human cells. Transient expression of the editor proteins (e.g. Cas9 protein) is desirable to reduce the risk of mutagenesis from o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486560/ https://www.ncbi.nlm.nih.gov/pubmed/30759231 http://dx.doi.org/10.1093/nar/gkz093 |