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Deoxyuridine in DNA has an inhibitory and promutagenic effect on RNA transcription by diverse RNA polymerases
dUTP is a close structural congener of dTTP and can be readily incorporated into DNA opposite to adenine during DNA replication leading to non-mutagenic dU/A base pairs (‘uracilation’). We find that dU/A pairs located within DNA transcriptional templates optimized for either T7 RNA polymerase (T7 RN...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486633/ https://www.ncbi.nlm.nih.gov/pubmed/30892639 http://dx.doi.org/10.1093/nar/gkz183 |