The ATPase mechanism of UvrA(2) reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair

The UvrA(2) dimer finds lesions in DNA and initiates nucleotide excision repair. Each UvrA monomer contains two essential ATPase sites: proximal (P) and distal (D). The manner whereby their activities enable UvrA(2) damage sensing and response remains to be clarified. We report three key findings fr...

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Detalles Bibliográficos
Autores principales: Case, Brandon C, Hartley, Silas, Osuga, Memie, Jeruzalmi, David, Hingorani, Manju M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486640/
https://www.ncbi.nlm.nih.gov/pubmed/30892613
http://dx.doi.org/10.1093/nar/gkz180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486640/
https://www.ncbi.nlm.nih.gov/pubmed/30892613
http://dx.doi.org/10.1093/nar/gkz180

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