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Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects
Mendelian randomization (MR) has emerged as a major tool for the investigation of causal relationship among traits, utilizing results from large-scale genome-wide association studies. Bias due to horizontal pleiotropy, however, remains a major concern. We propose a novel approach for robust and effi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486646/ https://www.ncbi.nlm.nih.gov/pubmed/31028273 http://dx.doi.org/10.1038/s41467-019-09432-2 |