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Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering
[Image: see text] α-Hemolysin (αHL), a β-barrel pore-forming toxin (βPFT), is secreted as a water-soluble monomer by Staphylococcus aureus. Upon binding to receptors on target cell membranes, αHL assembles to form heptameric membrane-spanning pores. We have previously engineered αHL to create a prot...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487460/ https://www.ncbi.nlm.nih.gov/pubmed/31041382 http://dx.doi.org/10.1021/acscentsci.8b00910 |