PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although their clinical significance is largely undescribed. The objective of this study was to e...

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Detalles Bibliográficos
Autores principales: Tanaka, Shota, Batchelor, Tracy T., Iafrate, A. John, Dias-Santagata, Dora, Borger, Darrell R., Ellisen, Leif W., Yang, Daniel, Louis, David N., Cahill, Daniel P., Chi, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487518/
https://www.ncbi.nlm.nih.gov/pubmed/31036078
http://dx.doi.org/10.1186/s40478-019-0720-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487518/
https://www.ncbi.nlm.nih.gov/pubmed/31036078
http://dx.doi.org/10.1186/s40478-019-0720-8

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