Cargando…
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma
Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although their clinical significance is largely undescribed. The objective of this study was to e...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487518/ https://www.ncbi.nlm.nih.gov/pubmed/31036078 http://dx.doi.org/10.1186/s40478-019-0720-8 |