The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease

Histone hypoacetylation is associated with dopaminergic neurodegeneration in Parkinson's disease (PD), because of an imbalance in the activities of the enzymes responsible for histone (de)acetylation. Correction of this imbalance, with histone deacetylase (HDAC) inhibiting agents, could be neur...

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Detalles Bibliográficos
Autores principales: Harrison, Ian F., Powell, Nicholas M., Dexter, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487684/
https://www.ncbi.nlm.nih.gov/pubmed/30269333
http://dx.doi.org/10.1111/jnc.14599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487684/
https://www.ncbi.nlm.nih.gov/pubmed/30269333
http://dx.doi.org/10.1111/jnc.14599

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