PTPRK suppresses progression and chemo‐resistance of colon cancer cells via direct inhibition of pro‐oncogenic CD133

Receptor‐type protein tyrosine phosphatase κ (PTPRK) is considered to be a candidate tumor suppressor. PTPRK dephosphorylates CD133, which is a stem cell marker; phosphorylated CD133 accelerates xenograft tumor growth of colon cancer cells through the activation of AKT, but the functional significan...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsushita, Masashi, Mori, Yusuke, Uchiumi, Kyosuke, Ogata, Takehiro, Nakamura, Mizuyo, Yoda, Hiroyuki, Soda, Hiroaki, Takiguchi, Nobuhiro, Nabeya, Yoshihiro, Shimozato, Osamu, Ozaki, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487712/
https://www.ncbi.nlm.nih.gov/pubmed/30947381
http://dx.doi.org/10.1002/2211-5463.12636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487712/
https://www.ncbi.nlm.nih.gov/pubmed/30947381
http://dx.doi.org/10.1002/2211-5463.12636

Ejemplares similares