Distinct cellular responses to replication stress leading to apoptosis or senescence

Replication stress (RS) is a major driver of genomic instability and tumorigenesis. Here, we investigated whether RS induced by the nucleotide analog fludarabine and specific kinase inhibitors [e.g. targeting checkpoint kinase 1 (Chk1) or ataxia telangiectasia and Rad3‐related (ATR)] led to apoptosi...

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Detalles Bibliográficos
Autores principales: Lukášová, Emilie, Řezáčová, Martina, Bačíková, Alena, Šebejová, Ludmila, Vávrová, Jiřina, Kozubek, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487726/
https://www.ncbi.nlm.nih.gov/pubmed/30982228
http://dx.doi.org/10.1002/2211-5463.12632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487726/
https://www.ncbi.nlm.nih.gov/pubmed/30982228
http://dx.doi.org/10.1002/2211-5463.12632

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