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Mutual regulation of MDM4 and TOP2A in cancer cell proliferation
MDM4 and topoisomerase IIα (TOP2A) are overexpressed in various human cancers. MDM4 acts as an oncoprotein which promotes cancer progression by inhibiting tumor suppressor p53. As a DNA replication‐ and cell division‐regulating enzyme, TOP2A is the main target of many anticancer therapy regimens; ho...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487731/ https://www.ncbi.nlm.nih.gov/pubmed/30672125 http://dx.doi.org/10.1002/1878-0261.12457 |