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Memantine selectively prevented the induction of dynamic allodynia by blocking Kir2.1 channel and inhibiting the activation of microglia in spinal dorsal horn of mice in spared nerve injury model
BACKGROUND: Memantine is one of the important clinical medications in treating moderate to severe Alzheimer disease. The effect of memantine on preventing or treating punctate allodynia has been thoroughly studied but not on the induction of dynamic allodynia. The aim of this study is to investigate...
Autores principales: | Chen, Yangyang, Shi, Yiqian, Wang, Guoxiang, Li, Yimei, Cheng, Longzhen, Wang, Yun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487752/ https://www.ncbi.nlm.nih.gov/pubmed/30845882 http://dx.doi.org/10.1177/1744806919838947 |
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