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It takes a team: a gain-of-function story of p53-R249S

Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and R273 with distinct molecular mechanisms. Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole ho...

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Detalles Bibliográficos
Autores principales: Wang, Huai, Liao, Peng, Zeng, Shelya X, Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487778/
https://www.ncbi.nlm.nih.gov/pubmed/30608603
http://dx.doi.org/10.1093/jmcb/mjy086